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While immunometabolism has long been recognized as important during an immune response, over the last decade there has been a keen interest in the identification of the players that provide the link between immune and metabolic responses in health and disease.
Understanding the mmune-metabolic interface is essential for our ability to understand and treat multiple diseases, as alterations in the metabolic state of the cells underlies the development and pathogenesis of type 2 diabetes, cardiovascular, neurological, infectious diseases, and cancer.
However, the plasticity and polarization of immune responses is also accompanied by a metabolic adaptation that is crucial to the prevention or resolution of infectious diseases and inflammatory responses.
Therefore, a greater understanding of the molecular and cellular pathways governing the immunological-metabolic crosstalk may provide opportunities for novel immunotherapeutic interventions to metabolic, autoimmune and inflammatory disorders.
More Information: Immunometabolism (uminho.pt)
